Since there is a limit of 3000 items to be displayed in some lists, it would be useful to have a filter that excludes caches already in a certain VGPS list. (you can include only ones already on a list)
For example, I want to build a vGPS of all the geocaches in Finland wit a given set of filters, but I can only display a list of 3000 at once. After I add these to a vGPS list, it would be great if I could then exclude the caches on that list from subsequent searches, In this way, I could quickly populate the vGPS list they way I want it.
There may be other reasons why excluding caches from a list would be useful. Comment below if you have a use case for this feature.